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Sigma
3′-Azido-3′-deoxythymidine
A2169 -
≥98% (HPLC)
DOWNLOAD MSDS (PDF)Synonym: AZT, Azidothymidine, ZDV, Zidovudine
CAS Number: 30516-87-1
Empirical Formula (Hill Notation): C10H13N5O4
Molecular Weight: 267.24
Beilstein Registry Number: 3595791
MDL number: MFCD00006536
PubChem Substance ID: 24278143
Properties
| Related Categories | AIDS and Viral Research Reagents, AN-AZ, Bioactive Small Molecules, Cell Biology, Chemical Biology, |
| assay | ≥98% (HPLC) |
| mp | 113-115 °C(lit.) |
| solubility | H2O: soluble50 mg/mL |
| storage temp. | −20°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... HIVE1(3095) mouse ... Slc29a1(63959) |
Description
Biochem/physiol Actions
Reverse transcriptase inhibitor active against HIV-1 virus.
Packaging
1 g in glass btl
100, 250 mg in glass btl
25 mg in poly btl
Price and Availability
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Documents
Certificate of Analysis
Certificate of Origin
| FT-NMR |  |
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Safety Information
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P281 |
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 36/37/39-45 |
| WGK Germany | 3 |
| RTECS | XP2072000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
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References
Agarwal, R.P., et al., Cross-resistance of dideoxycytidine-resistant cell lines to azidothymidine. Biochem. Pharmacol. 58, 1603-1608, (1999) Abstract
Wu, D., et al., Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat. Brain Res. 791, 313, (1998) Abstract
Difalco, M.R., et al., Efficacy of an insulin-like growth factor-interleukin-3 fusion protein in reversing the hematopoietic toxicity associated with azidothymidine in mice. J. Pharmacol. Exp. Ther. 284, 449-454, (1998) Abstract
Kamata, M., et al., Reassessing The Role Of APOBEC3G In Human Immunodeficiency Virus Type 1 Infection Of Quiescent CD4+ T-cells. PLoS Pathog. 5, e1000342, (2009) Abstract
Khan, Z., et al., Plant Thymidine Kinase 1: A Novel Efficient Suicide Gene For Malignant Glioma Therapy. Neuro-Oncol. 12, 549-58, (2010) Abstract
Merck 14,10123
Corp MSDS 1, 325:C / FT-NMR 1 (3), 393:A / RegBook 1 (2), 2587:G / Structure Index 1, 409:A:5
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